⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22018246 | 0.75 | LMNA (0.33) | — | |
| SCHEMBL22018249 | 0.70 | MEN1 (0.32) | — | |
| SCHEMBL22594125 | 0.64 | SLC6A2 (0.33) | — | |
| SCHEMBL8989069 | 0.63 | SLC6A2 (0.37) | — | |
| SCHEMBL19586044 | 0.62 | CRBN (0.49) | — | |
| SCHEMBL29080163 | 0.62 | — | — | |
| SCHEMBL8662680 | 0.61 | SLC6A2 (0.33) | — | |
| SCHEMBL16528524 | 0.59 | — | — | |
| SCHEMBL205130 | 0.59 | — | — | |
| SCHEMBL7776540 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11185592-B2 | Spirocyclic degronimers for target protein degradation | C4 THERAPEUTICS, INC. (US) | 2021-11-30 | — | — | US | disclosed |
| US-20210106688-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | US | disclosed |
| US-10660968-B2 | Spirocyclic degronimers for target protein degradation | C4 THERAPEUTICS, INC. (US) | 2020-05-26 | — | — | US | disclosed |