Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30708692 | 0.78 | APOBEC3A (0.61) | APOBEC3AAPOBEC3GPDE10ASMPD3AXL | |
| SCHEMBL2340742 | 0.75 | APOBEC3A (0.58) | APOBEC3AAPOBEC3GPDE10ASMPD3AXL | |
| SCHEMBL21863369 | 0.75 | APOBEC3A (0.53) | APOBEC3AAPOBEC3GPDE10ASMPD3AXL | |
| SCHEMBL2181213 | 0.75 | APOBEC3A (0.53) | APOBEC3AAPOBEC3GPDE10ASMPD3AXL | |
| SCHEMBL9792881 | 0.75 | APOBEC3A (0.53) | APOBEC3AAPOBEC3GPDE10ASMPD3AXL | |
| SCHEMBL5435763 | 0.75 | APOBEC3A (0.53) | APOBEC3AAPOBEC3GPDE10ASMPD3AXL | |
| SCHEMBL4789376 | 0.75 | APOBEC3A (0.53) | APOBEC3AAPOBEC3GPDE10ASMPD3AXL | |
| SCHEMBL1441278 | 0.75 | APOBEC3A (0.53) | APOBEC3AAPOBEC3GPDE10ASMPD3AXL | |
| SCHEMBL30118007 | 0.73 | APOBEC3A (0.56) | APOBEC3AAPOBEC3GPDE10ASMPD3AXL | |
| Hydrochloric Acid SCHEMBL4800485 | 0.73 | APOBEC3A (0.51) | APOBEC3AAPOBEC3GPDE10ASMPD3PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157119-A1 | MACROCYCLIC COMPOUNDS AND USES THEREOF | Turning Point Therapeutics, Inc. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157119-A1 | MACROCYCLIC COMPOUNDS AND USES THEREOF | CSF3R, CSF1R, FLT3 | APOBEC3A 3993/4885APOBEC3G 4188/4885PDE10A 1472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.