Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | EEF2K | O00418 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22020117 | 0.87 | GAA (0.46) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL21963218 | 0.87 | GAA (0.46) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL31651305 | 0.82 | CYP1A2 (0.39) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL22019806 | 0.80 | GAA (0.59) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL24978308 | 0.79 | CYP1A2 (0.36) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL22020361 | 0.78 | USP2 (0.40) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL24978485 | 0.77 | GAA (0.42) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL24978523 | 0.76 | TDP1 (0.37) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL30162183 | 0.76 | TDP1 (0.37) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL22019942 | 0.74 | ACHE (0.55) | CYP1A2KDM4EMEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880666-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-06-28 | — | — | EP | disclosed |
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |