Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.62 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22020141 | 0.91 | USP30 (0.61) | USP30RIOK2ARGSK3BDYRK1A | |
| SCHEMBL4271035 | 0.90 | USP30 (0.60) | USP30RIOK2ARGSK3BDYRK1A | |
| SCHEMBL16254222 | 0.80 | USP30 (0.64) | USP30RIOK2JAK2TYK2ALDH1A1 | |
| SCHEMBL22653435 | 0.76 | USP30 (1.00) | USP30 | |
| SCHEMBL29878272 | 0.76 | USP30 (1.00) | USP30 | |
| SCHEMBL12004497 | 0.75 | USP30 (0.58) | USP30RIOK2FFAR4MAP3K12MEN1 | |
| SCHEMBL12004494 | 0.75 | USP30 (0.58) | USP30RIOK2FFAR4MAP3K12MEN1 | |
| SCHEMBL6862768 | 0.75 | USP30 (0.58) | USP30RIOK2FFAR4MAP3K12MEN1 | |
| SCHEMBL16254943 | 0.72 | RIOK2 (0.60) | USP30RIOK2ARJAK2TYK2 | |
| SCHEMBL23060730 | 0.71 | RIOK2 (0.61) | USP30RIOK2ARALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |