Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21963400 | 0.89 | NLRP3 (0.48) | NLRP3GAACYP1A2NPSR1USP2 | |
| SCHEMBL22265280 | 0.89 | NLRP3 (0.48) | NLRP3GAACYP1A2NPSR1USP2 | |
| SCHEMBL22021099 | 0.87 | NLRP3 (0.48) | NLRP3GAACYP1A2NPSR1USP2 | |
| SCHEMBL22021144 | 0.87 | NLRP3 (0.48) | NLRP3GAACYP1A2NPSR1USP2 | |
| SCHEMBL21963201 | 0.86 | GAA (0.46) | NLRP3GAACYP1A2NPSR1USP2 | |
| SCHEMBL24978041 | 0.84 | NLRP3 (0.52) | NLRP3GAACYP1A2NPSR1USP2 | |
| SCHEMBL21963257 | 0.81 | CYP1A2 (0.42) | NLRP3GAACYP1A2NPSR1USP2 | |
| SCHEMBL21963250 | 0.81 | GAA (0.64) | GAACYP1A2NPSR1USP2KDM4E | |
| SCHEMBL22020311 | 0.81 | NLRP3 (0.48) | NLRP3GAACYP1A2NPSR1USP2 | |
| SCHEMBL30120777 | 0.81 | NLRP3 (0.48) | NLRP3GAACYP1A2NPSR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102096-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |