Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 5/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197591 | 0.96 | F2 (0.52) | F2BACE1PTGESTGFBR1LIMK2 | |
| SCHEMBL15946028 | 0.77 | HTR6 (0.50) | PTGESLIMK2ADRB3HTR6ADRB2 | |
| SCHEMBL2196090 | 0.77 | F2 (0.53) | F2TGFBR1HTR6 | |
| SCHEMBL3132483 | 0.75 | HTR6 (0.58) | ADRB3HTR6 | |
| SCHEMBL3134261 | 0.74 | ADRB3 (0.47) | PTGESLIMK2ADRB3HTR6ADRB2 | |
| SCHEMBL4605486 | 0.72 | HTR6 (0.52) | ADRB3HTR6ADRB2ADRB1 | |
| SCHEMBL27840648 | 0.72 | HTR6 (0.52) | PTGESADRB3HTR6ADRB2ADRB1 | |
| SCHEMBL14020393 | 0.72 | HTR6 (0.52) | ADRB3HTR6ADRB2ADRB1 | |
| SCHEMBL4605482 | 0.72 | HTR6 (0.52) | ADRB3HTR6ADRB2ADRB1 | |
| SCHEMBL4793028 | 0.72 | HTR6 (0.52) | ADRB3HTR6ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340242-A2 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-06 | — | — | EP | disclosed |
| WO-2010048332-A2 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-04-29 | — | — | WO | disclosed |