Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 2/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202216 | 1.00 | CRBN (0.44) | CRBNTDP2GRM5GRM1NPY1R | |
| SCHEMBL13719272 | 0.83 | CRBN (0.39) | CRBNNPY1RNPY5RMAP3K5MAOA | |
| SCHEMBL13719274 | 0.80 | CRBN (0.42) | CRBNTDP2NPY1RNPY5RMAP3K5 | |
| SCHEMBL16850272 | 0.79 | CRBN (0.54) | CRBNGRM5GRM1RORCMAOA | |
| SCHEMBL25894733 | 0.76 | CRBN (0.54) | CRBNNPY1RNPY5R | |
| SCHEMBL7238057 | 0.75 | CRBN (0.56) | CRBNNPY1RNPY5RMAOA | |
| SCHEMBL31252792 | 0.75 | CRBN (0.56) | CRBNNPY1RNPY5RMAOA | |
| SCHEMBL13829131 | 0.75 | TDP2 (0.45) | CRBNTDP2MAPK1 | |
| SCHEMBL2202780 | 0.75 | CRBN (0.37) | CRBNNPY1RNPY5RMAP3K5 | |
| SCHEMBL25673270 | 0.74 | CRBN (0.50) | CRBNNPY1RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |