Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.53 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.52 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | TRPM4 | Q8TD43 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22022916 | 0.91 | MEN1 (0.70) | ACLYMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22022886 | 0.91 | ACLY (0.72) | ACLYMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22022929 | 0.90 | ACLY (0.65) | ACLYMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22022913 | 0.90 | ACLY (0.59) | ACLYMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22022880 | 0.89 | HCAR2 (0.66) | ACLYMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22022901 | 0.89 | ACLY (0.66) | ACLYMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22022866 | 0.87 | ACLY (0.61) | ACLYMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22022883 | 0.87 | ACLY (0.63) | ACLYMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22022864 | 0.86 | ACLY (0.75) | ACLYMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22022873 | 0.84 | ACLY (0.60) | ACLYMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220054438-A1 | KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2022-02-24 | — | — | US | claimed |
| EP-3662908-A1 | MODULATING COMPOUNDS OF KCHIP2 AND ITS USE FOR THE TREATMENT OF CARDIOVASCULAR PATHOLOGIES | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2020-06-10 | — | — | EP | claimed |
| US-20220054438-A1 | KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2022-02-24 | — | — | US | disclosed |
| US-20220054438-A1 | KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2022-02-24 | — | — | US | disclosed |
| EP-3662908-A1 | MODULATING COMPOUNDS OF KCHIP2 AND ITS USE FOR THE TREATMENT OF CARDIOVASCULAR PATHOLOGIES | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2020-06-10 | — | — | EP | disclosed |
| EP-3662908-A1 | MODULATING COMPOUNDS OF KCHIP2 AND ITS USE FOR THE TREATMENT OF CARDIOVASCULAR PATHOLOGIES | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2020-06-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220054438-A1 | KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | KCNK2, KCNT2, KCNT1 | ACLY 3559/4885MEN1 4366/4885KMT2A 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.