Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.63 |
| ▸ | KDM5A | P29375 | 1/20 | 0.63 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.63 |
| ▸ | ACLY | P53396 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.57 |
| ▸ | KDM6B | O15054 | 1/20 | 0.54 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.54 |
| ▸ | WNT3A | P56704 | 2/20 | 0.54 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22022888 | 0.90 | GRIK1 (0.56) | KDM4CKDM5AKDM5BACLYMEN1 | |
| SCHEMBL22022931 | 0.89 | HCAR2 (0.62) | KDM4CACLYGRIK1KDM6BKDM4D | |
| SCHEMBL22022864 | 0.89 | ACLY (0.75) | KDM4CKDM5AKDM5BACLYMEN1 | |
| SCHEMBL22022897 | 0.84 | MEN1 (0.58) | KDM4CKDM5AKDM5BACLYMEN1 | |
| SCHEMBL22022924 | 0.83 | MEN1 (0.60) | KDM4CKDM5AKDM5BACLYMEN1 | |
| SCHEMBL22022933 | 0.83 | MEN1 (0.68) | KDM4CKDM5AKDM5BACLYMEN1 | |
| SCHEMBL22022868 | 0.83 | KMT2A (0.68) | KDM4CKDM5AKDM5BACLYMEN1 | |
| SCHEMBL22022874 | 0.82 | HCAR2 (0.56) | KDM4CKDM5AKDM5BACLYMEN1 | |
| SCHEMBL1309256 | 0.82 | MEN1 (0.78) | KDM4CKDM5AKDM5BACLYMEN1 | |
| SCHEMBL22022916 | 0.82 | MEN1 (0.70) | KDM4CKDM5AKDM5BACLYMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220054438-A1 | KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2022-02-24 | — | — | US | disclosed |
| US-20220054438-A1 | KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2022-02-24 | — | — | US | disclosed |
| EP-3890734-A1 | KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2021-10-13 | — | — | EP | disclosed |
| WO-2020115019-A1 | KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) | 2020-06-11 | — | — | WO | disclosed |
| EP-3662908-A1 | MODULATING COMPOUNDS OF KCHIP2 AND ITS USE FOR THE TREATMENT OF CARDIOVASCULAR PATHOLOGIES | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2020-06-10 | — | — | EP | disclosed |
| EP-3662908-A1 | MODULATING COMPOUNDS OF KCHIP2 AND ITS USE FOR THE TREATMENT OF CARDIOVASCULAR PATHOLOGIES | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2020-06-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220054438-A1 | KCHIP2 MODULATOR COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | KCNK2, KCNT2, KCNT1 | KDM4C 2740/4885KDM5A 1698/4885KDM5B 1705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.