Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.79 |
| ▸ | TNKS | O95271 | 1/20 | 0.79 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.79 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.79 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.79 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.79 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.79 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.79 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.79 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.79 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.76 |
| ▸ | BRD4 | O60885 | 5/20 | 0.58 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.49 |
| ▸ | TERT | O14746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pj34 SCHEMBL29375455 | 0.88 | PARP1 (1.00) | PARP1TNKSPARP15PARP14PARP10 | |
| Pj34 SCHEMBL29355630 | 0.88 | PARP1 (1.00) | PARP1TNKSPARP15PARP14PARP10 | |
| Pj34 SCHEMBL422317 | 0.88 | PARP1 (1.00) | PARP1TNKSPARP15PARP14PARP10 | |
| Pj34 SCHEMBL5074001 | 0.87 | PARP1 (0.98) | PARP1TNKSPARP15PARP14PARP10 | |
| Pj34 SCHEMBL29419962 | 0.87 | PARP1 (0.98) | PARP1TNKSPARP15PARP14PARP10 | |
| Pj34 SCHEMBL29478302 | 0.87 | PARP1 (0.98) | PARP1TNKSPARP15PARP14PARP10 | |
| Pj34 SCHEMBL31153313 | 0.86 | TRPM2 (1.00) | PARP1TNKSPARP15PARP14PARP10 | |
| SCHEMBL20286631 | 0.85 | PARP1 (0.80) | PARP1TNKSPARP15PARP14PARP10 | |
| SCHEMBL6691492 | 0.82 | PARP1 (0.75) | PARP1TNKSPARP15PARP14PARP10 | |
| SCHEMBL9961294 | 0.82 | PARP1 (0.75) | PARP1TNKSPARP15PARP14PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200155521-A1 | PHARMACEUTICAL COMBINATION FOR TREATMENT OF CANCER | ARQULE, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155521-A1 | PHARMACEUTICAL COMBINATION FOR TREATMENT OF CANCER | TP53, KRAS, VHL | PARP1 1298/4885TNKS 1658/4885PARP15 1946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.