Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.82 |
| ▸ | BRAF | P15056 | 12/20 | 0.54 |
| ▸ | CSF1R | P07333 | 4/20 | 0.53 |
| ▸ | KIT | P10721 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024863 | 0.93 | PIKFYVE (0.80) | PIKFYVEBRAFCSF1RKITKDR | |
| SCHEMBL22025465 | 0.93 | PIKFYVE (0.72) | PIKFYVEBRAFCSF1RKITKDR | |
| SCHEMBL22024534 | 0.93 | PIKFYVE (0.85) | PIKFYVEBRAFCSF1RKITKDR | |
| SCHEMBL22024690 | 0.91 | PIKFYVE (0.81) | PIKFYVEBRAFCSF1RKITKDR | |
| SCHEMBL22024533 | 0.91 | PIKFYVE (0.81) | PIKFYVEBRAFCSF1RKITKDR | |
| SCHEMBL22024700 | 0.91 | PIKFYVE (0.81) | PIKFYVEBRAFCSF1RKITKDR | |
| SCHEMBL22024870 | 0.90 | PIKFYVE (1.00) | PIKFYVEBRAFCSF1RKITKDR | |
| SCHEMBL30675086 | 0.90 | PIKFYVE (1.00) | PIKFYVEBRAFCSF1RKITKDR | |
| SCHEMBL22024864 | 0.90 | PIKFYVE (0.85) | PIKFYVEBRAFCSF1RKITKDR | |
| SCHEMBL22024701 | 0.89 | PIKFYVE (0.79) | PIKFYVEBRAFCSF1RKITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | XIAMEN UNIVERSITY (CN) | 2022-06-07 | — | — | US | disclosed |
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | PIKFYVE, PIK3CA, PIK3C2A | PIKFYVE 1/4885BRAF 65/4885CSF1R 3197/4885 |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | PIKFYVE, PIK3CA, PIK3C2A | PIKFYVE 1/4885BRAF 65/4885CSF1R 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.