Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.55 |
| ▸ | BCR | P11274 | 4/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 7/20 | 0.49 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | PRKCA | P17252 | 3/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.47 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.47 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.47 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.47 |
| ▸ | AGPS | O00116 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024638 | 0.93 | RXFP1 (0.51) | ABL1BCRRXFP1EGFRPDGFRB | |
| SCHEMBL22025019 | 0.85 | PIKFYVE (0.65) | ABL1BCRRXFP1PIKFYVEEGFR | |
| SCHEMBL21943013 | 0.81 | MAPK14 (0.54) | ABL1BCRRXFP1PIKFYVEEGFR | |
| SCHEMBL22024696 | 0.81 | ABL1 (0.67) | ABL1BCRPIKFYVEEGFRPDGFRB | |
| SCHEMBL22024869 | 0.80 | PIKFYVE (0.73) | ABL1BCRPIKFYVEEGFRPDGFRB | |
| SCHEMBL21943070 | 0.79 | MEN1 (0.53) | ABL1BCRRXFP1PIKFYVEEGFR | |
| SCHEMBL21943534 | 0.78 | KDR (0.58) | ABL1BCRPIKFYVEEGFRPDGFRB | |
| SCHEMBL21943735 | 0.77 | BRAF (0.51) | ABL1BCRRXFP1PIKFYVEEGFR | |
| SCHEMBL21943517 | 0.76 | TEK (0.57) | ABL1BCRPIKFYVEEGFRPDGFRB | |
| SCHEMBL18804561 | 0.73 | DDR1 (0.81) | ABL1BCRPIKFYVEEGFRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | XIAMEN UNIVERSITY (CN) | 2022-06-07 | — | — | US | disclosed |
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | PIKFYVE, PIK3CA, PIK3C2A | ABL1 1429/4885BCR 1416/4885RXFP1 2857/4885 |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | PIKFYVE, PIK3CA, PIK3C2A | ABL1 1429/4885BCR 1416/4885RXFP1 2857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.