Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | HCK | P08631 | 2/20 | 0.56 |
| ▸ | BTK | Q06187 | 2/20 | 0.56 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 15/20 | 0.55 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.52 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.51 |
| ▸ | PLEKHG3 | A1L390 | 1/20 | 0.51 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.51 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.51 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.51 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.51 |
| ▸ | AGPS | O00116 | 1/20 | 0.51 |
| ▸ | MYO1F | O00160 | 1/20 | 0.51 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.51 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024644 | 0.92 | ABL1 (0.69) | ABL1HCKBTKNR2C2LYN | |
| SCHEMBL22024645 | 0.85 | BRAF (0.68) | ABL1HCKBTKLYNCSF1R | |
| SCHEMBL22025311 | 0.82 | BRAF (0.68) | ABL1LYNCSF1RKITBRAF | |
| SCHEMBL18804561 | 0.78 | DDR1 (0.81) | ABL1HCKBTKLYNCSF1R | |
| SCHEMBL22025379 | 0.77 | ABL1 (0.69) | ABL1HCKBTKNR2C2LYN | |
| SCHEMBL10106165 | 0.75 | BRAF (0.75) | BRAF | |
| SCHEMBL1653558 | 0.75 | ABL1 (0.79) | ABL1HCKBTKNR2C2LYN | |
| SCHEMBL10106131 | 0.74 | BRAF (0.69) | ABL1LYNCSF1RKITBRAF | |
| SCHEMBL4697696 | 0.74 | BRAF (0.86) | ABL1HCKBTKLYNCSF1R | |
| SCHEMBL22025467 | 0.74 | ABL1 (0.71) | ABL1LYNCSF1RKITBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | XIAMEN UNIVERSITY (CN) | 2022-06-07 | — | — | US | disclosed |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | PIKFYVE, PIK3CA, PIK3C2A | ABL1 1429/4885HCK 740/4885BTK 594/4885 |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | PIKFYVE, PIK3CA, PIK3C2A | ABL1 1429/4885HCK 740/4885BTK 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.