Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 14/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 11/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15587052 | 1.00 | PTGER4 (0.44) | PTGER4PTGER2NPSR1HPGDTSHR | |
| SCHEMBL16819443 | 1.00 | PTGER4 (0.44) | PTGER4PTGER2NPSR1HPGDTSHR | |
| SCHEMBL16819439 | 1.00 | PTGER4 (0.44) | PTGER4PTGER2NPSR1HPGDTSHR | |
| SCHEMBL16819436 | 1.00 | PTGER4 (0.44) | PTGER4PTGER2NPSR1HPGDTSHR | |
| SCHEMBL28432254 | 0.89 | PTGER4 (0.44) | PTGER4PTGER2 | |
| SCHEMBL15551553 | 0.89 | PTGER4 (0.44) | PTGER4PTGER2 | |
| SCHEMBL15551554 | 0.89 | PTGER4 (0.44) | PTGER4PTGER2 | |
| SCHEMBL16408738 | 0.81 | NPC1 (0.34) | PTGER4PTGER2NPSR1HPGDMAPK1 | |
| SCHEMBL20852642 | 0.80 | PTGER4 (0.33) | PTGER4NPSR1HPGDTSHRMAPK1 | |
| SCHEMBL17475210 | 0.80 | PTGER2 (0.36) | PTGER4PTGER2NPSR1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176162-B1 | DIFLUOROLACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASE AND CONDITIONS | CAYMAN CHEMICAL CO INC (US) | 2020-05-27 | — | — | EP | disclosed |