Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 5/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | ABL1 | P00519 | 3/20 | 0.57 |
| ▸ | EGFR | P00533 | 3/20 | 0.57 |
| ▸ | PRKCB | P05771 | 3/20 | 0.57 |
| ▸ | INSR | P06213 | 3/20 | 0.57 |
| ▸ | LCK | P06239 | 3/20 | 0.57 |
| ▸ | FYN | P06241 | 3/20 | 0.57 |
| ▸ | LYN | P07948 | 3/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | PRKCA | P17252 | 3/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.57 |
| ▸ | AKT1 | P31749 | 3/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024880 | 0.92 | EPHB4 (0.61) | EPHB4KDRDDR1DDR2HSD17B10 | |
| SCHEMBL22025033 | 0.92 | EPHB4 (0.57) | EPHB4KDRDDR1DDR2HSD17B10 | |
| SCHEMBL22024568 | 0.92 | KDR (0.53) | EPHB4KDRDDR1DDR2HSD17B10 | |
| SCHEMBL22025542 | 0.84 | EPHB4 (0.59) | EPHB4KDRDDR1DDR2HSD17B10 | |
| SCHEMBL22024565 | 0.84 | KDR (0.53) | EPHB4KDRDDR1DDR2HSD17B10 | |
| SCHEMBL22024648 | 0.83 | EPHB4 (0.52) | EPHB4KDRDDR1DDR2HSD17B10 | |
| SCHEMBL22024719 | 0.78 | PIK3CA (0.53) | HSD17B10LMNAMAPK1FYNCLK4 | |
| SCHEMBL22119546 | 0.76 | BRAF (0.82) | EPHB4KDRDDR1DDR2HSD17B10 | |
| SCHEMBL22024647 | 0.75 | EPHB4 (0.61) | EPHB4KDRDDR1DDR2HSD17B10 | |
| SCHEMBL22024855 | 0.74 | KDR (0.53) | EPHB4KDRLMNAABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | XIAMEN UNIVERSITY (CN) | 2022-06-07 | — | — | US | disclosed |
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | PIKFYVE, PIK3CA, PIK3C2A | EPHB4 4427/4885KDR 148/4885DDR1 1422/4885 |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | PIKFYVE, PIK3CA, PIK3C2A | EPHB4 4427/4885KDR 148/4885DDR1 1422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.