Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 15/20 | 0.59 |
| ▸ | KDR | P35968 | 7/20 | 0.59 |
| ▸ | FLT1 | P17948 | 3/20 | 0.59 |
| ▸ | TEK | Q02763 | 3/20 | 0.59 |
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | PRKCB | P05771 | 2/20 | 0.59 |
| ▸ | INSR | P06213 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | FYN | P06241 | 2/20 | 0.59 |
| ▸ | LYN | P07948 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | PRKCA | P17252 | 2/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.59 |
| ▸ | AKT1 | P31749 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | SYK | P43405 | 2/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024880 | 0.92 | EPHB4 (0.61) | EPHB4KDRFLT1TEKABL1 | |
| SCHEMBL22024565 | 0.92 | KDR (0.53) | EPHB4KDRFLT1TEKABL1 | |
| SCHEMBL22024568 | 0.92 | KDR (0.53) | EPHB4KDRFLT1TEKABL1 | |
| SCHEMBL22025032 | 0.84 | EPHB4 (0.57) | EPHB4KDRFLT1TEKABL1 | |
| SCHEMBL22025033 | 0.84 | EPHB4 (0.57) | EPHB4KDRFLT1TEKABL1 | |
| SCHEMBL22024854 | 0.82 | EPHB4 (0.60) | EPHB4KDRFLT1TEKABL1 | |
| SCHEMBL22024877 | 0.77 | BCDIN3D (0.50) | IRAK1IRAK4BCDIN3D | |
| SCHEMBL22119546 | 0.75 | BRAF (0.82) | EPHB4KDRABL1EGFRPRKCB | |
| SCHEMBL22024647 | 0.75 | EPHB4 (0.61) | EPHB4KDRFLT1TEKABL1 | |
| SCHEMBL4697696 | 0.75 | BRAF (0.86) | EPHB4KDRTEKABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | XIAMEN UNIVERSITY (CN) | 2022-06-07 | — | — | US | disclosed |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | XIAMEN UNIVERSITY (CN) | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352354-B2 | Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | PIKFYVE, PIK3CA, PIK3C2A | EPHB4 4427/4885KDR 148/4885FLT1 421/4885 |
| US-20200165246-A1 | SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | PIKFYVE, PIK3CA, PIK3C2A | EPHB4 4427/4885KDR 148/4885FLT1 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.