Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 19/20 | 0.65 |
| ▸ | PTGER2 | P43116 | 13/20 | 0.57 |
| ▸ | PTGER3 | P43115 | 6/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18943127 | 0.85 | PTGER4 (0.73) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL22025490 | 0.84 | PTGER4 (0.74) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL22025485 | 0.83 | PTGER4 (0.73) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL22025636 | 0.80 | PTGER4 (0.59) | PTGER4PTGER2PTGER3 | |
| SCHEMBL18943378 | 0.80 | PTGER4 (0.84) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL18943379 | 0.79 | PTGER4 (0.75) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL22025652 | 0.79 | PTGER4 (0.62) | PTGER4PTGER2 | |
| SCHEMBL22025163 | 0.79 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL15550695 | 0.79 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL18123985 | 0.79 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176162-B1 | DIFLUOROLACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASE AND CONDITIONS | CAYMAN CHEMICAL CO INC (US) | 2020-05-27 | — | — | EP | disclosed |