Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 10/20 | 0.73 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.73 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | TERT | O14746 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | PPARD | Q03181 | 3/20 | 0.47 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | FABP4 | P15090 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22025487 | 0.85 | PTGER4 (0.65) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL18123934 | 0.84 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2LMNA | |
| SCHEMBL15549258 | 0.84 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2LMNA | |
| SCHEMBL19328437 | 0.84 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2LMNA | |
| SCHEMBL16819470 | 0.84 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2LMNA | |
| SCHEMBL21658906 | 0.81 | PTGER4 (0.57) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL21658917 | 0.81 | PTGER4 (0.57) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL18123950 | 0.80 | PTGER4 (0.77) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL18123948 | 0.80 | PTGER4 (0.77) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL16819525 | 0.80 | PTGER4 (0.77) | PTGER4PTGER2PTGER3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176162-B1 | DIFLUOROLACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASE AND CONDITIONS | CAYMAN CHEMICAL CO INC (US) | 2020-05-27 | — | — | EP | disclosed |
| EP-3175852-A1 | DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS | Cayman Chemical Company, Incorporated (US) | 2017-06-07 | — | — | EP | disclosed |