Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.40 |
| ▸ | KIT | P10721 | 8/20 | 0.40 |
| ▸ | FLT3 | P36888 | 6/20 | 0.40 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | FLT4 | P35916 | 3/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.35 |
| ▸ | PLK4 | O00444 | 2/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.35 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | INSR | P06213 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202662 | 1.00 | KDR (0.40) | KDRPDGFRBKITFLT3RET | |
| SCHEMBL12225705 | 0.95 | KDR (0.39) | KDRPDGFRBKITFLT3RET | |
| SCHEMBL2197502 | 0.95 | KDR (0.39) | KDRPDGFRBKITFLT3RET | |
| SCHEMBL2197512 | 0.95 | KDR (0.39) | KDRPDGFRBKITFLT3RET | |
| SCHEMBL2201522 | 0.94 | KDR (0.42) | KDRPDGFRBKITFLT3RET | |
| SCHEMBL12225670 | 0.94 | KDR (0.42) | KDRPDGFRBKITFLT3RET | |
| SCHEMBL2201527 | 0.94 | KDR (0.42) | KDRPDGFRBKITFLT3RET | |
| SCHEMBL2200036 | 0.93 | KDR (0.42) | KDRPDGFRBKITFLT3RET | |
| SCHEMBL12225654 | 0.93 | KDR (0.42) | KDRPDGFRBKITFLT3RET | |
| SCHEMBL2200040 | 0.93 | KDR (0.42) | KDRPDGFRBKITFLT3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455535-B2 | Heteroaryl dihydroindolones as kinase inhibitors | ALLERGAN, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20110257238-A1 | Heteroaryl Dihydroindolones as Kinase Inhibitors | ALLERGAN, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| US-7977351-B2 | Heteroaryl dihydroindolones as kinase inhibitors | ALLERGAN, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20080045526-A1 | HETEROARYL DIHYDROINDOLONES AS KINASE INHIBITORS | ALLERGAN, INC. | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257238-A1 | Heteroaryl Dihydroindolones as Kinase Inhibitors | REN, JAK2, ABL1 | KDR 25/4885PDGFRB 11/4885KIT 367/4885 |
| US-20080045526-A1 | HETEROARYL DIHYDROINDOLONES AS KINASE INHIBITORS | REN, JAK2, ABL1 | KDR 25/4885PDGFRB 11/4885KIT 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.