Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL771941 | 0.95 | KCNH2 (0.42) | KCNH2NR1I2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL771846 | 0.95 | KCNH2 (0.41) | KCNH2NR1I2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL12510477 | 0.94 | KCNH2 (0.42) | KCNH2NR1I2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL772942 | 0.93 | NR1I2 (0.41) | KCNH2NR1I2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL774124 | 0.93 | KCNH2 (0.41) | KCNH2NR1I2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL772487 | 0.92 | LNPEP (0.43) | KCNH2NR1I2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL771931 | 0.92 | KCNH2 (0.42) | KCNH2NR1I2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL771379 | 0.91 | KCNH2 (0.42) | KCNH2NR1I2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL771658 | 0.91 | KCNH2 (0.42) | KCNH2NR1I2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL773343 | 0.91 | KCNH2 (0.42) | KCNH2NR1I2CYP3A4CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |