Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.54 |
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407447 | 0.92 | MET (0.63) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL372122 | 0.87 | MET (0.65) | METFLT3KDRAXL | |
| SCHEMBL372123 | 0.83 | MET (0.55) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL371812 | 0.83 | MET (0.65) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL411581 | 0.83 | MET (0.66) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL371601 | 0.83 | MET (0.66) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL371555 | 0.83 | MET (0.63) | METFLT3KDRAXL | |
| SCHEMBL407815 | 0.83 | MET (0.69) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL371955 | 0.83 | MET (0.64) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL407116 | 0.83 | MET (0.64) | METFLT3KDRAXLPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2213661-B1 | c-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2011-07-20 | — | — | EP | disclosed |