Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 4/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22029633 | 0.84 | RBP4 (0.37) | RBP4ADORA1ESR2CREBBPBRD4 | |
| SCHEMBL17870541 | 0.82 | RBP4 (0.39) | RBP4ADORA1ESR2CREBBPBRD4 | |
| SCHEMBL17870535 | 0.81 | RBP4 (0.39) | RBP4ADORA1ESR2CREBBPBRD4 | |
| SCHEMBL22029668 | 0.80 | NAMPT (0.36) | RBP4ADORA1ESR2CREBBPNAMPT | |
| SCHEMBL22615700 | 0.80 | NAMPT (0.35) | RBP4ADORA1ESR2CREBBPBRD4 | |
| SCHEMBL14520683 | 0.78 | ESR2 (0.41) | RBP4ADORA1ESR2CREBBPBRD4 | |
| SCHEMBL4792110 | 0.78 | ADORA1 (0.46) | RBP4ADORA1ESR2CREBBPBRD4 | |
| SCHEMBL25430237 | 0.77 | ADORA1 (0.43) | RBP4ADORA1ESR2CREBBPBRD4 | |
| SCHEMBL17870544 | 0.76 | RBP4 (0.40) | RBP4ADORA1ESR2CREBBPBRD4 | |
| SCHEMBL17878107 | 0.76 | MAPK1 (0.42) | RBP4ADORA1ESR2CREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478683-B1 | DIAZEPINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEPATITIS B INFECTIONS | NOVIRA THERAPEUTICS INC (US) | 2021-07-21 | — | — | EP | disclosed |
| US-20210188849-A1 | DIAZEPINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEPATITIS B INFECTIONS | NOVIRA THERAPEUTICS INC (US) | 2021-06-24 | — | — | US | disclosed |
| US-10975077-B2 | Diazepinone derivatives and their use in the treatment of hepatitis B infections | NOVIRA THERAPEUTICS, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20200181144-A1 | DIAZEPINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEPATITIS B INFECTIONS | NOVIRA THERAPEUTICS, INC. | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188849-A1 | DIAZEPINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEPATITIS B INFECTIONS | HAVCR2, NR1H4, NR1H2 | RBP4 2459/4885ADORA1 552/4885ESR2 519/4885 |
| US-20200181144-A1 | DIAZEPINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEPATITIS B INFECTIONS | HAVCR2, NR1H4, NR1H2 | RBP4 2459/4885ADORA1 552/4885ESR2 519/4885 |
| US-10975077-B2 | Diazepinone derivatives and their use in the treatment of hepatitis B infections | HAVCR2, NR1H4, NR1H2 | RBP4 2459/4885ADORA1 552/4885ESR2 519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.