Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203098 | 1.00 | KMT2A (0.45) | KMT2AMCHR1CHRM4OPRM1CACNA2D1 | |
| SCHEMBL2202933 | 0.89 | MCHR1 (0.47) | KMT2AMCHR1NPSR1 | |
| SCHEMBL2202927 | 0.89 | MCHR1 (0.47) | KMT2AMCHR1NPSR1 | |
| SCHEMBL13973770 | 0.87 | KMT2A (0.42) | KMT2AMCHR1OPRM1CACNA2D1MAPT | |
| SCHEMBL2197635 | 0.85 | KMT2A (0.53) | KMT2AOPRM1CACNA2D1NOTUMSCN9A | |
| SCHEMBL2200002 | 0.85 | KMT2A (0.47) | KMT2AOPRM1CACNA2D1NOTUMSCN9A | |
| SCHEMBL2203346 | 0.85 | KMT2A (0.45) | KMT2ANOTUMSCN9APIM1SCN10A | |
| SCHEMBL2201648 | 0.83 | KMT2A (0.49) | KMT2APIM1NPY5RMAPTRAB9A | |
| SCHEMBL2199925 | 0.82 | KMT2A (0.50) | KMT2AMCHR1SCN9ASCN10AMAPT | |
| SCHEMBL27788063 | 0.81 | KMT2A (0.49) | KMT2AOPRM1CACNA2D1NOTUMSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |