Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20149624 | 0.89 | RET (0.41) | RETPDE8BKMT2AMAPTALDH1A1 | |
| SCHEMBL21158720 | 0.86 | RET (0.40) | RETPDE8BKMT2AMAPTALDH1A1 | |
| SCHEMBL20148684 | 0.85 | RET (0.43) | RETPDE8BKMT2AMAPTALDH1A1 | |
| SCHEMBL20071330 | 0.85 | RET (0.39) | RETPDE8BKMT2AMAPTALDH1A1 | |
| SCHEMBL20071328 | 0.83 | OPRM1 (0.42) | RETALDH1A1OPRM1OPRK1 | |
| SCHEMBL20149633 | 0.78 | OPRM1 (0.39) | RETALDH1A1OPRM1OPRK1 | |
| SCHEMBL18080916 | 0.73 | MAPT (0.46) | RETPDE8BKMT2AMAPTALDH1A1 | |
| SCHEMBL20071347 | 0.72 | RET (0.39) | RETKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL22030755 | 0.71 | RET (0.39) | RET | |
| SCHEMBL20148694 | 0.70 | RET (0.40) | RETALDH1A1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3523301-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-05-27 | — | — | EP | disclosed |