E-Methyl Cinnamate

E-Methyl Cinnamate

SCHEMBL22032604

C1C2CC3CC1CC(C2)C3.COC(=O)C=Cc1ccccc1

nearest known ligand 0.58

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.58
CA12 O43570 1/20 0.57
CA1 P00915 1/20 0.57
CA2 P00918 1/20 0.57
TYR P14679 1/20 0.57
CA7 P43166 1/20 0.57
CA9 Q16790 1/20 0.57
CA14 Q9ULX7 1/20 0.57
KMT2A Q03164 3/20 0.53
ALDH1A1 P00352 2/20 0.51
GLA P06280 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
PTPN1 P18031 1/20 0.50
SMN1; SMN2 Q16637 4/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
LMNA P02545 2/20 0.49
TTR P02766 1/20 0.49
APP P05067 1/20 0.49
HDAC3 O15379 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
E-Methyl Cinnamate SCHEMBL22032603 1.00 ESR1 (0.58) ESR1CA12CA1CA2TYR
E-Methyl Cinnamate SCHEMBL27554806 0.89 CA12 (0.69) CA12CA1CA2TYRCA7
E-Methyl Cinnamate SCHEMBL1862419 0.89 CA12 (0.69) CA12CA1CA2TYRCA7
E-Methyl Cinnamate SCHEMBL901224 0.89 CA12 (0.69) CA12CA1CA2TYRCA7
E-Methyl Cinnamate SCHEMBL101530 0.89 CA12 (0.69) CA12CA1CA2TYRCA7
E-Methyl Cinnamate SCHEMBL27554805 0.89 CA12 (0.69) CA12CA1CA2TYRCA7
E-Methyl Cinnamate SCHEMBL2425288 0.89 CA12 (0.69) CA12CA1CA2TYRCA7
E-Methyl Cinnamate SCHEMBL112062 0.89 CA12 (0.69) CA12CA1CA2TYRCA7
E-Methyl Cinnamate SCHEMBL7642084 0.88 CA12 (0.67) CA12CA1CA2TYRCA7
E-Methyl Cinnamate SCHEMBL6327040 0.88 CA12 (0.67) CA12CA1CA2TYRCA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220089616-A1 CARBORANE-BASED HISTONE DEACETYLASE (HDAC) INHIBITORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-03-24 US disclosed
WO-2020117976-A1 CARBORANE-BASED HISTONE DEACETYLASE (HDAC) INHIBITORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-06-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089616-A1 CARBORANE-BASED HISTONE DEACETYLASE (HDAC) INHIBITORS HDAC5, HDAC1, HDAC7 ESR1 4742/4885CA12 128/4885CA1 38/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.