Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 6/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.47 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MYLK | Q15746 | 1/20 | 0.46 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | XPO1 | O14980 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22033574 | 0.95 | TP53 (0.45) | P2RX1P2RX4P2RX7TMPRSS4TP53 | |
| SCHEMBL22033381 | 0.91 | RXFP1 (0.52) | P2RX1P2RX4P2RX7TMPRSS4TP53 | |
| SCHEMBL22033338 | 0.91 | P2RX1 (0.48) | P2RX1P2RX4P2RX7TMPRSS4MEN1 | |
| SCHEMBL22032910 | 0.88 | P2RX1 (0.45) | P2RX1P2RX4P2RX7TMPRSS4TP53 | |
| SCHEMBL22082621 | 0.87 | TP53 (0.44) | TP53MEN1KMT2AMALT1 | |
| SCHEMBL22033064 | 0.86 | TP53 (0.54) | P2RX1P2RX4P2RX7TP53MEN1 | |
| SCHEMBL22032966 | 0.86 | KMT2A (0.51) | TP53MEN1KMT2A | |
| SCHEMBL22033572 | 0.86 | MEN1 (0.45) | P2RX1P2RX4P2RX7TMPRSS4MEN1 | |
| SCHEMBL22032865 | 0.84 | TP53 (0.56) | P2RX1TMPRSS4TP53MEN1KMT2A | |
| SCHEMBL22032948 | 0.84 | TP53 (0.54) | TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020117877-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE | AQUINNAH PHARMACEUTICALS, INC. (US) | 2020-06-11 | — | — | WO | disclosed |
| WO-2020117877-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE | AQUINNAH PHARMACEUTICALS, INC. (US) | 2020-06-11 | — | — | WO | disclosed |