Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.55 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CCR4 | P51679 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13852799 | 0.83 | SLC22A12 (0.54) | SLC22A12PGRLMNAMAPTMEN1 | |
| SCHEMBL20575861 | 0.82 | SLC22A12 (0.56) | SLC22A12PGRLMNAMEN1KMT2A | |
| SCHEMBL22034355 | 0.81 | CCR4 (0.55) | SLC22A12PGRLMNAMAPTMEN1 | |
| SCHEMBL7569855 | 0.80 | SLC22A12 (0.58) | SLC22A12LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL20575865 | 0.79 | PTGES2 (0.57) | MAPTALDH1A1CCR4SMN1; SMN2GAA | |
| SCHEMBL526675 | 0.77 | CYP17A1 (0.83) | MEN1KMT2ACYP17A1 | |
| SCHEMBL526782 | 0.77 | CYP17A1 (0.74) | CYP17A1 | |
| SCHEMBL30602443 | 0.75 | CYP17A1 (0.55) | LMNAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL526859 | 0.75 | CYP17A1 (0.55) | LMNAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8819732 | 0.74 | PSEN1 (0.72) | LMNAMAPTMEN1KMT2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12404248-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2025-09-02 | — | — | US | disclosed |
| EP-4201924-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2024-10-23 | — | — | EP | disclosed |
| US-20240287004-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2024-08-29 | — | — | US | disclosed |
| US-11945784-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2024-04-02 | — | — | US | disclosed |
| EP-3891130-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2023-10-25 | — | — | EP | disclosed |
| EP-3891130-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2023-10-25 | — | — | EP | disclosed |
| EP-4201924-A1 | IRE1 SMALL MOLECULE INHIBITORS | Cornell University (US) | 2023-06-28 | — | — | EP | disclosed |
| EP-4201924-A1 | IRE1 SMALL MOLECULE INHIBITORS | Cornell University (US) | 2023-06-28 | — | — | EP | disclosed |
| US-20220024878-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2022-01-27 | — | — | US | disclosed |
| EP-3891130-A1 | IRE1 SMALL MOLECULE INHIBITORS | Cornell University (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2020117634-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-06-11 | — | — | WO | disclosed |
| WO-2020117634-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY (US) | 2020-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11945784-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | SLC22A12 2943/4885PGR 2679/4885LMNA 2127/4885 |
| US-20240287004-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | SLC22A12 2943/4885PGR 2679/4885LMNA 2127/4885 |
| US-20220024878-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | SLC22A12 2943/4885PGR 2679/4885LMNA 2127/4885 |
| US-12404248-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | SLC22A12 2943/4885PGR 2679/4885LMNA 2127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.