⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24397739 | 0.84 | ATM (0.35) | — | |
| SCHEMBL17465657 | 0.83 | — | — | |
| SCHEMBL25530700 | 0.83 | — | — | |
| SCHEMBL25530694 | 0.83 | — | — | |
| SCHEMBL25530702 | 0.83 | — | — | |
| SCHEMBL28771452 | 0.82 | CHRNB2 (0.39) | — | |
| SCHEMBL21899175 | 0.82 | — | — | |
| SCHEMBL12492345 | 0.82 | DPP4 (0.35) | — | |
| SCHEMBL21899169 | 0.82 | GBA1 (0.33) | — | |
| SCHEMBL29156969 | 0.82 | HTT (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542248-B2 | Methods and compositions for inhibiting the interaction of menin with MLL proteins | KURA ONCOLOGY, INC. (US) | 2023-01-03 | — | — | US | disclosed |
| US-20200165224-A1 | METHODS AND COMPOSITIONS FOR INHIBITING THE INTERACTION OF MENIN WITH MLL PROTEINS | WELLSPRING BIOSCIENCES LLC | 2020-05-28 | — | — | US | disclosed |