⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22788781 | 0.79 | — | — | |
| SCHEMBL12337289 | 0.77 | CYP2D6 (0.37) | — | |
| SCHEMBL24843749 | 0.75 | ALOX15 (0.32) | — | |
| SCHEMBL26241221 | 0.75 | PIK3CD (0.36) | — | |
| SCHEMBL12049766 | 0.74 | — | — | |
| SCHEMBL11919130 | 0.74 | — | — | |
| SCHEMBL12673901 | 0.74 | KDM4E (0.39) | — | |
| SCHEMBL12232845 | 0.72 | — | — | |
| SCHEMBL23482056 | 0.71 | TSHR (0.30) | — | |
| SCHEMBL10207376 | 0.69 | TSHR (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542248-B2 | Methods and compositions for inhibiting the interaction of menin with MLL proteins | KURA ONCOLOGY, INC. (US) | 2023-01-03 | — | — | US | disclosed |
| US-20200165224-A1 | METHODS AND COMPOSITIONS FOR INHIBITING THE INTERACTION OF MENIN WITH MLL PROTEINS | WELLSPRING BIOSCIENCES LLC | 2020-05-28 | — | — | US | disclosed |