Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.73 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.72 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.72 |
| ▸ | PDE2A | O00408 | 1/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.72 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.72 |
| ▸ | PDE6D | O43924 | 1/20 | 0.72 |
| ▸ | PDE8A | O60658 | 1/20 | 0.72 |
| ▸ | PDE9A | O76083 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | HTR1A | P08908 | 1/20 | 0.72 |
| ▸ | PDE6A | P16499 | 1/20 | 0.72 |
| ▸ | PDE6G | P18545 | 1/20 | 0.72 |
| ▸ | PDE4A | P27815 | 1/20 | 0.72 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.72 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22041432 | 0.96 | PDE5A (0.75) | PDE5AHDAC1HDAC2HDAC6PDE3B | |
| SCHEMBL24430053 | 0.94 | PDE5A (0.71) | PDE5AHDAC1HDAC2HDAC6PDE3B | |
| SCHEMBL24239380 | 0.90 | PDE5A (0.71) | PDE5AHDAC1HDAC2HDAC6PDE3B | |
| SCHEMBL23370711 | 0.90 | PDE5A (0.70) | PDE5AHDAC1HDAC2HDAC6PDE3B | |
| SCHEMBL21995695 | 0.90 | PDE5A (0.71) | PDE5AHDAC1HDAC2HDAC6PDE3B | |
| SCHEMBL31064951 | 0.90 | PDE5A (0.71) | PDE5AHDAC1HDAC2HDAC6PDE3B | |
| SCHEMBL24239278 | 0.90 | PDE5A (0.71) | PDE5AHDAC1HDAC2HDAC6PDE3B | |
| SCHEMBL22041040 | 0.89 | PDE5A (0.84) | PDE5AHDAC1HDAC2HDAC6PDE3B | |
| SCHEMBL24239354 | 0.89 | PDE5A (0.70) | PDE5AHDAC1HDAC2HDAC6PDE3B | |
| SCHEMBL21995286 | 0.89 | PDE5A (0.72) | PDE5AHDAC1HDAC2HDAC6PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220031704-A1 | NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | TOPADUR PHARMA AG (CH) | 2022-02-03 | — | — | US | disclosed |
| WO-2020109354-A1 | NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | TOPADUR PHARMA AG (CH) | 2020-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220031704-A1 | NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | PDE9A, PDE5A, PDE2A | PDE5A 2/4885HDAC1 1307/4885HDAC2 1486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.