Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 16/20 | 0.47 |
| ▸ | MET | P08581 | 13/20 | 0.47 |
| ▸ | MERTK | Q12866 | 8/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HCK | P08631 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407596 | 0.92 | AXL (0.53) | AXLMETMERTKKDRFLT1 | |
| SCHEMBL411533 | 0.86 | MET (0.46) | AXLMETMERTKKDRKIT | |
| SCHEMBL409973 | 0.81 | MET (0.57) | AXLMETMERTKKDRFLT1 | |
| SCHEMBL21200539 | 0.81 | AXL (0.53) | AXLMETMERTKKDRFLT1 | |
| SCHEMBL29529487 | 0.81 | AXL (0.53) | AXLMETMERTKKDRFLT1 | |
| SCHEMBL21201097 | 0.80 | AXL (0.50) | AXLMETMERTKKDRFLT1 | |
| SCHEMBL29529447 | 0.80 | AXL (0.50) | AXLMETMERTKKDRFLT1 | |
| SCHEMBL139146 | 0.80 | MET (0.41) | AXLMETMERTKKDRFLT1 | |
| SCHEMBL21200914 | 0.80 | AXL (0.51) | AXLMETMERTKKDRFLT1 | |
| SCHEMBL29529490 | 0.80 | AXL (0.51) | AXLMETMERTKKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2213661-B1 | c-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2011-07-20 | — | — | EP | disclosed |