Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.52 |
| ▸ | MELK | Q14680 | 4/20 | 0.52 |
| ▸ | CDC7 | O00311 | 3/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.52 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.47 |
| ▸ | AXL | P30530 | 4/20 | 0.47 |
| ▸ | FLT4 | P35916 | 4/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | CLK2 | P49760 | 4/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.47 |
| ▸ | CAMK2B | Q13554 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22044490 | 0.83 | BACE1 (0.53) | FLT3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL22044125 | 0.81 | JAK3 (0.64) | DYRK1AMAP4K4CLK4MELKCDC7 | |
| SCHEMBL22044122 | 0.81 | CAMKK2 (0.72) | DYRK1AMAP4K4CLK4MELKCDC7 | |
| SCHEMBL22044049 | 0.80 | JAK2 (0.46) | FLT3KDRROCK1ROCK2CHRM2 | |
| SCHEMBL8240376 | 0.79 | AKT1 (0.65) | DYRK1AMAP4K4CLK4MELKDYRK1B | |
| SCHEMBL22044904 | 0.79 | DYRK1A (0.51) | DYRK1AMAP4K4CLK4MELKCDC7 | |
| SCHEMBL8242383 | 0.78 | AKT1 (0.51) | DYRK1AMAP4K4CLK4MELKCDC7 | |
| SCHEMBL24440651 | 0.77 | CDC7 (0.52) | DYRK1AMAP4K4CLK4MELKCDC7 | |
| SCHEMBL857524 | 0.75 | ROCK1 (0.67) | CAMKK2ROCK1CDK2 | |
| SCHEMBL22044129 | 0.74 | AKT1 (0.66) | DYRK1AMAP4K4CLK4MELKCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200172521-A1 | Five-Membered-Fused-Six-Membered Aza-Aromatic Ring Compound, Preparation Method Thereof, Pharmaceutical Composition And Application Thereof | Amcure Biosciences Pte. Ltd. (SG) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172521-A1 | Five-Membered-Fused-Six-Membered Aza-Aromatic Ring Compound, Preparation Method Thereof, Pharmaceutical Composition And Application Thereof | KRAS, NRAS, RASSF5 | DYRK1A 1738/4885MAP4K4 2087/4885CLK4 3622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.