SCHEMBL22045238

SCHEMBL22045238

O=c1[nH]c2ccccc2n2c1nc1ccccc12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.55
RXFP1 Q9HBX9 1/20 0.55
POLB P06746 2/20 0.54
KDM4E B2RXH2 1/20 0.54
ALDH1A1 P00352 1/20 0.54
MAPT P10636 1/20 0.54
G6PD P11413 1/20 0.54
PKM P14618 1/20 0.54
HPGD P15428 1/20 0.54
ALOX12 P18054 1/20 0.54
HKDC1 Q2TB90 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
ADORA3 P0DMS8 10/20 0.52
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
ADORA2A P29274 1/20 0.48
ADORA1 P30542 1/20 0.48
PDE2A O00408 1/20 0.47
PDE6D O43924 1/20 0.47
PDE8A O60658 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23856092 0.84 KDM4E (0.52) NPSR1RXFP1POLBKDM4EALDH1A1
SCHEMBL29999716 0.84 KDM4E (0.52) NPSR1RXFP1POLBKDM4EALDH1A1
SCHEMBL22045231 0.84 AURKA (0.44) NPSR1RXFP1POLBKDM4EALDH1A1
SCHEMBL22045666 0.84 TP53 (0.51) NPSR1RXFP1POLBKDM4EALDH1A1
SCHEMBL21208525 0.83 PDE2A (0.52) NPSR1RXFP1POLBKDM4EALDH1A1
SCHEMBL22045239 0.83 KDM4E (0.51) NPSR1RXFP1POLBKDM4EALDH1A1
SCHEMBL21208437 0.79 ZAP70 (0.41) NPSR1RXFP1POLBKDM4EALDH1A1
SCHEMBL9052411 0.78 POLB (0.55) NPSR1RXFP1POLBKDM4EALDH1A1
SCHEMBL13431707 0.76 ZAP70 (0.53) POLBKDM4EALDH1A1MAPTPKM
SCHEMBL1698065 0.75 KDM4E (0.53) NPSR1KDM4EALDH1A1MAPTPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113169274-A Compounds for electronic devices 默克专利有限公司 2021-07-23 CN disclosed
WO-2020109524-A1 COMPOUNDS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2020-06-04 WO disclosed