SCHEMBL22045239

SCHEMBL22045239

O=c1[nH]c2ccc(-c3ccccc3)cc2n2c1nc1ccccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.51
ALDH1A1 P00352 6/20 0.51
HPGD P15428 6/20 0.51
MAPT P10636 2/20 0.51
PKM P14618 2/20 0.51
POLB P06746 2/20 0.51
G6PD P11413 1/20 0.51
ALOX12 P18054 1/20 0.51
HKDC1 Q2TB90 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
ADORA3 P0DMS8 4/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
LMNA P02545 2/20 0.47
HSD17B10 Q99714 2/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
TP53 P04637 1/20 0.47
GAA P10253 1/20 0.47
ADORA2A P29274 1/20 0.41
ADORA2B P29275 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22045238 0.83 NPSR1 (0.55) KDM4EALDH1A1HPGDMAPTPKM
SCHEMBL22045231 0.83 AURKA (0.44) KDM4EALDH1A1HPGDMAPTPKM
SCHEMBL25569975 0.81 ALDH1A1 (0.55) KDM4EALDH1A1HPGDMAPTPKM
SCHEMBL20041553 0.77 KDM4E (0.50) KDM4EALDH1A1HPGDMAPTPKM
SCHEMBL20041527 0.75 KDM4E (0.51) KDM4EALDH1A1HPGDMAPTPKM
SCHEMBL22045666 0.75 TP53 (0.51) KDM4EALDH1A1HPGDMAPTPKM
SCHEMBL22045667 0.74 KDM4E (0.56) KDM4EALDH1A1HPGDMAPTPKM
SCHEMBL22357668 0.73 KDM4E (0.46) KDM4EALDH1A1HPGDMAPTPKM
SCHEMBL20821348 0.73 HPGD (0.59) KDM4EALDH1A1HPGDMAPTPKM
SCHEMBL21208437 0.73 ZAP70 (0.41) KDM4EALDH1A1HPGDMAPTPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020109524-A1 COMPOUNDS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2020-06-04 WO disclosed