Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 20/20 | 0.65 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592116 | 0.83 | TLR8 (0.59) | TLR8TLR7 | |
| SCHEMBL1800626 | 0.79 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL20623483 | 0.77 | TLR8 (0.64) | TLR8TLR7 | |
| SCHEMBL27078282 | 0.76 | TLR8 (0.84) | TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL27078481 | 0.74 | TLR8 (0.89) | TLR8TLR7 | |
| SCHEMBL19416364 | 0.72 | TLR8 (0.39) | TLR8TLR7 | |
| SCHEMBL27078336 | 0.72 | TLR8 (0.71) | TLR8TLR7 | |
| SCHEMBL27078327 | 0.72 | TLR8 (0.83) | TLR8TLR7 | |
| SCHEMBL29066392 | 0.71 | TLR8 (0.70) | TLR8TLR7 | |
| SCHEMBL1238468 | 0.71 | TLR8 (0.67) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11046671-B2 | Dihydropyrimidinyl benzazepine carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2021-06-29 | — | — | US | disclosed |
| US-20200172513-A1 | DIHYDROPYRIMIDINYL BENZAZEPINE CARBOXAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172513-A1 | DIHYDROPYRIMIDINYL BENZAZEPINE CARBOXAMIDE COMPOUNDS | TLR8, TLR1, TLR5 | TLR8 1/4885TLR7 8/4885 |
| US-11046671-B2 | Dihydropyrimidinyl benzazepine carboxamide compounds | TLR8, TLR1, TLR5 | TLR8 1/4885TLR7 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.