Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10207559 | 0.88 | RAB9A (0.62) | MAPTKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1697621 | 0.88 | MAPT (0.67) | MAPTKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL13490873 | 0.87 | SMN1; SMN2 (0.56) | MAPTKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3534158 | 0.87 | RAB9A (0.56) | MAPTKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL28414075 | 0.87 | SMN1; SMN2 (0.56) | MAPTKMT2ASMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL514849 | 0.85 | RAB9A (0.59) | MAPTKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1965344 | 0.84 | RAB9A (0.53) | MAPTKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL7070030 | 0.83 | MAPT (0.53) | MAPTKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL31487539 | 0.83 | KMT2A (0.52) | MAPTKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL17132355 | 0.82 | MAPT (0.59) | MAPTKMT2ASMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |