Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980450 | 0.84 | AOC3 (0.44) | NPC1RAB9AAOC3SMN1; SMN2CA12 | |
| SCHEMBL22737287 | 0.82 | AOC3 (0.42) | NPC1RAB9AAOC3SMN1; SMN2CA12 | |
| SCHEMBL23189283 | 0.79 | AOC3 (0.44) | NPC1RAB9AAOC3SMN1; SMN2KMT2A | |
| SCHEMBL24310595 | 0.78 | CES2 (0.42) | NPC1RAB9AAOC3SMN1; SMN2KMT2A | |
| SCHEMBL19216110 | 0.77 | AOC3 (0.52) | NPC1RAB9AAOC3SMN1; SMN2CA12 | |
| SCHEMBL20344592 | 0.76 | TDP1 (0.39) | NPC1RAB9AAOC3CA12CA9 | |
| SCHEMBL23189268 | 0.75 | HPGD (0.41) | NPC1RAB9AAOC3KMT2AMEN1 | |
| SCHEMBL19654872 | 0.75 | AOC3 (0.48) | NPC1RAB9AAOC3CA12CA9 | |
| SCHEMBL23011657 | 0.73 | — | — | |
| SCHEMBL23337476 | 0.72 | AOC3 (0.42) | NPC1RAB9AAOC3SMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |