Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15964620 | 0.80 | KDM5B (0.40) | ADORA2AADORA2BADORA1PDE9AKDM5B | |
| SCHEMBL15964597 | 0.79 | LMNA (0.42) | ADORA2AADORA2BADORA1ALDH1A1 | |
| SCHEMBL15964621 | 0.79 | KDM5B (0.41) | ADORA2AADORA2BADORA1PDE9AKDM5B | |
| SCHEMBL15964836 | 0.79 | CHEK2 (0.39) | ADORA2AADORA2BADORA1PDE9ANPC1 | |
| SCHEMBL23927505 | 0.78 | LMNA (0.44) | ADORA2AADORA2BADORA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17324360 | 0.78 | LMNA (0.44) | ADORA2AADORA2BADORA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL19980499 | 0.78 | CHEK2 (0.41) | ADORA2AADORA2BADORA1PDE9APDE5A | |
| SCHEMBL22272515 | 0.76 | KDM4E (0.40) | ADORA2AADORA2BADORA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22272514 | 0.72 | KDM4E (0.42) | SMN1; SMN2PDE4DALDH1A1 | |
| SCHEMBL15456025 | 0.71 | PDE9A (0.44) | ADORA2AADORA2BADORA1PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |