Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22017318 | 0.89 | NR1H2 (0.51) | DRD3DRD4NR1H2POLBEED | |
| SCHEMBL20691645 | 0.79 | DRD3 (0.43) | DRD3DRD4NR1H2POLBGAA | |
| SCHEMBL22615344 | 0.77 | MEN1 (0.46) | NR1H2POLBTP53ALDH1A1KMT2A | |
| SCHEMBL22621702 | 0.76 | NR1H2 (0.42) | NR1H2POLBTP53KMT2ALMNA | |
| SCHEMBL26122508 | 0.76 | NR1H2 (0.41) | NR1H2POLBCREBBPALDH1A1LMNA | |
| SCHEMBL29946264 | 0.74 | MEN1 (0.45) | POLBTP53KMT2ALMNAMEN1 | |
| SCHEMBL25412076 | 0.74 | POLB (0.49) | POLBTP53KMT2AHPGDMEN1 | |
| SCHEMBL30915375 | 0.74 | GPR119 (0.42) | NR1H2POLBTP53ALDH1A1KMT2A | |
| SCHEMBL19781281 | 0.73 | NR1H2 (0.42) | NR1H2POLBALDH1A1KMT2ALMNA | |
| SCHEMBL31605818 | 0.72 | NR1H2 (0.43) | DRD4NR1H2POLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660018-A1 | PIPERAZINE HETEROARYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE OF SAME IN MEDICINE | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2020-06-03 | — | — | EP | disclosed |