Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 6/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28380939 | 1.00 | CYP1A2 (0.48) | CYP1A2CYP3A4TSHRCYP2D6HSD17B10 | |
| SCHEMBL16671440 | 1.00 | CYP1A2 (0.48) | CYP1A2CYP3A4TSHRCYP2D6HSD17B10 | |
| SCHEMBL3614301 | 1.00 | CYP1A2 (0.48) | CYP1A2CYP3A4TSHRCYP2D6HSD17B10 | |
| SCHEMBL28376808 | 1.00 | CYP1A2 (0.48) | CYP1A2CYP3A4TSHRCYP2D6HSD17B10 | |
| SCHEMBL21338822 | 1.00 | CYP1A2 (0.48) | CYP1A2CYP3A4TSHRCYP2D6HSD17B10 | |
| SCHEMBL21338814 | 1.00 | CYP1A2 (0.48) | CYP1A2CYP3A4TSHRCYP2D6HSD17B10 | |
| SCHEMBL20594755 | 0.86 | KMT2A (0.43) | CYP2D6ALDH1A1KMT2A | |
| SCHEMBL20594448 | 0.86 | KMT2A (0.43) | CYP2D6ALDH1A1KMT2A | |
| SCHEMBL3595828 | 0.86 | KMT2A (0.43) | CYP2D6ALDH1A1KMT2A | |
| SCHEMBL20594447 | 0.86 | KMT2A (0.43) | CYP2D6ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110831936-B | Substituted cyanopyrrolidines with DUB inhibitor activity | 特殊治疗有限公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-3642196-B1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS DUB INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2022-08-17 | — | — | EP | disclosed |
| US-11059809-B2 | Substituted cyanopyrrolidines with activity as DUB inhibitors | MISSION THERAPEUTICS LIMITED (GB) | 2021-07-13 | — | — | US | disclosed |
| US-20210002262-A1 | CYANOPYRROLIDINES AS USP30 INHIBITORS AND FIBROSIS TREATMENT | MISSION THERAPEUTICS LIMITED (GB) | 2021-01-07 | — | — | US | disclosed |
| US-20200172519-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS DUB INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-06-04 | — | — | US | disclosed |
| CN-110831936-A | Substituted cyanopyrrolidines with DUB inhibitor activity | 特殊治疗有限公司 | 2020-02-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002262-A1 | CYANOPYRROLIDINES AS USP30 INHIBITORS AND FIBROSIS TREATMENT | USP30, USP39, USP36 | CYP1A2 1498/4885CYP3A4 2054/4885TSHR 4455/4885 |
| US-20200172519-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS DUB INHIBITORS | USP30, USP39, USP1 | CYP1A2 2173/4885CYP3A4 2278/4885TSHR 4490/4885 |
| US-11059809-B2 | Substituted cyanopyrrolidines with activity as DUB inhibitors | USP30, USP1, USP47 | CYP1A2 1734/4885CYP3A4 2013/4885TSHR 4456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.