Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20691687 | 0.90 | CSNK1E (0.47) | CSNK1ERAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL22054148 | 0.90 | CSNK1E (0.48) | CSNK1ERAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL20691578 | 0.88 | CSNK1E (0.49) | CSNK1ERAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL20691684 | 0.86 | NAMPT (0.46) | CSNK1ERAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL21958276 | 0.86 | CSNK1E (0.45) | CSNK1ERAB9ANPC1SMN1; SMN2CSNK1D | |
| SCHEMBL17925979 | 0.82 | CSNK1E (0.54) | CSNK1ERAB9ANPC1MAPTCSNK1D | |
| SCHEMBL22053571 | 0.81 | CSNK1E (0.39) | CSNK1EMAPTCSNK1DALDH1A1ENPP2 | |
| SCHEMBL20691573 | 0.80 | CSNK1E (0.40) | CSNK1ECSNK1D | |
| SCHEMBL20691558 | 0.79 | CSNK1E (0.43) | CSNK1EMAPTCSNK1DP2RY12 | |
| SCHEMBL20691551 | 0.79 | RAB9A (0.42) | RAB9ANPC1SMN1; SMN2MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660018-A1 | PIPERAZINE HETEROARYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE OF SAME IN MEDICINE | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2020-06-03 | — | — | EP | disclosed |