Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.52 |
| ▸ | JAK3 | P52333 | 19/20 | 0.52 |
| ▸ | JAK1 | P23458 | 13/20 | 0.52 |
| ▸ | JAK2 | O60674 | 11/20 | 0.52 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22055017 | 0.89 | TYK2 (0.65) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23878776 | 0.89 | TYK2 (0.65) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL24995625 | 0.86 | TYK2 (0.63) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL22054117 | 0.85 | TYK2 (0.50) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23889710 | 0.82 | TYK2 (0.52) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23889557 | 0.80 | TYK2 (0.53) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL22054127 | 0.80 | TYK2 (0.53) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL24174490 | 0.79 | JAK3 (0.43) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL24174461 | 0.79 | JAK3 (0.43) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL22054527 | 0.79 | TYK2 (0.63) | TYK2JAK3JAK1JAK2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020108613-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏豪森药业集团有限公司 | 2020-06-04 | — | — | WO | disclosed |