Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.43 |
| ▸ | TYK2 | P29597 | 17/20 | 0.43 |
| ▸ | JAK1 | P23458 | 12/20 | 0.43 |
| ▸ | JAK2 | O60674 | 11/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24174461 | 1.00 | JAK3 (0.43) | JAK3TYK2JAK1JAK2PLK4 | |
| SCHEMBL24995625 | 0.82 | TYK2 (0.63) | JAK3TYK2JAK1JAK2 | |
| SCHEMBL22055017 | 0.82 | TYK2 (0.65) | JAK3TYK2JAK1JAK2P2RX3 | |
| SCHEMBL23878776 | 0.82 | TYK2 (0.65) | JAK3TYK2JAK1JAK2P2RX3 | |
| SCHEMBL22055329 | 0.79 | TYK2 (0.52) | JAK3TYK2JAK1JAK2P2RX3 | |
| SCHEMBL23889710 | 0.78 | TYK2 (0.52) | JAK3TYK2JAK1JAK2P2RX3 | |
| SCHEMBL23889557 | 0.77 | TYK2 (0.53) | JAK3TYK2JAK1JAK2RET | |
| SCHEMBL24175051 | 0.76 | JAK3 (0.69) | JAK3TYK2JAK1JAK2P2RX3 | |
| SCHEMBL24174781 | 0.76 | JAK3 (0.69) | JAK3TYK2JAK1JAK2P2RX3 | |
| SCHEMBL24174782 | 0.76 | JAK3 (0.69) | JAK3TYK2JAK1JAK2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916747-A | Fused heterocyclic derivative and application thereof in medicine | 四川海思科制药有限公司 | 2023-04-04 | — | — | CN | disclosed |
| WO-2022002118-A1 | FUSED-RING HETEROCYCLE DERIVATIVE AND MEDICAL USE THEREOF | 四川海思科制药有限公司 | 2022-01-06 | — | — | WO | disclosed |