Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 13/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | TYK2 | P29597 | 5/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23878890 | 0.76 | TYK2 (0.49) | PLK4JAK2TYK2JAK3JAK1 | |
| SCHEMBL30227729 | 0.76 | TYK2 (0.49) | PLK4JAK2TYK2JAK3JAK1 | |
| SCHEMBL22055393 | 0.76 | TYK2 (0.49) | PLK4JAK2TYK2JAK3JAK1 | |
| SCHEMBL24995883 | 0.76 | PLK4 (0.48) | PLK4JAK2TYK2JAK3JAK1 | |
| SCHEMBL23889636 | 0.76 | PLK4 (0.57) | PLK4NTRK1PAK4SHMT2 | |
| SCHEMBL23878923 | 0.71 | TYK2 (0.58) | PLK4JAK2TYK2JAK3JAK1 | |
| SCHEMBL22055110 | 0.71 | TYK2 (0.58) | PLK4JAK2TYK2JAK3JAK1 | |
| SCHEMBL23878858 | 0.70 | PLK4 (0.48) | PLK4JAK2TYK2JAK3JAK1 | |
| SCHEMBL22055266 | 0.70 | PLK4 (0.48) | PLK4JAK2TYK2JAK3JAK1 | |
| SCHEMBL23878942 | 0.68 | TYK2 (0.50) | PLK4JAK2TYK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020108613-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏豪森药业集团有限公司 | 2020-06-04 | — | — | WO | disclosed |