Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.49 |
| ▸ | JAK2 | O60674 | 16/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FER | P16591 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | STAT5A | P42229 | 1/20 | 0.46 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220676 | 0.86 | JAK2 (0.55) | JAK3JAK2AURKANTRK1AURKB | |
| SCHEMBL218403 | 0.79 | JAK2 (0.59) | JAK3JAK2AURKANTRK1AURKB | |
| SCHEMBL220721 | 0.79 | JAK3 (0.79) | JAK3JAK2AURKANTRK1AURKB | |
| SCHEMBL220720 | 0.77 | JAK2 (0.76) | JAK3JAK2AURKANTRK1AURKB | |
| SCHEMBL220217 | 0.77 | JAK2 (0.76) | JAK3JAK2AURKANTRK1AURKB | |
| SCHEMBL220606 | 0.76 | JAK2 (0.55) | JAK3JAK2AURKANTRK1AURKB | |
| SCHEMBL3950465 | 0.74 | NTRK1 (0.53) | JAK3JAK2AURKANTRK1AURKB | |
| SCHEMBL218817 | 0.73 | JAK2 (0.73) | JAK3JAK2 | |
| SCHEMBL13904391 | 0.72 | JAK2 (0.50) | JAK3JAK2AURKANTRK1AURKB | |
| SCHEMBL220649 | 0.72 | JAK2 (0.53) | JAK3JAK2AURKANTRK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088784-B2 | 4-(3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer | ASTRAZENECA AB (SE) | 2012-01-03 | — | — | US | disclosed |