Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.53 |
| ▸ | AURKA | O14965 | 6/20 | 0.53 |
| ▸ | GRK6 | P43250 | 4/20 | 0.53 |
| ▸ | IGF1R | P08069 | 4/20 | 0.53 |
| ▸ | GRK4 | P32298 | 1/20 | 0.53 |
| ▸ | GRK5 | P34947 | 1/20 | 0.53 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.53 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 10/20 | 0.52 |
| ▸ | JAK3 | P52333 | 10/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588686 | 0.87 | JAK3 (0.68) | NTRK1AURKAGRK6IGF1RJAK2 | |
| SCHEMBL220676 | 0.87 | JAK2 (0.55) | NTRK1AURKAGRK6JAK2JAK3 | |
| SCHEMBL13904391 | 0.87 | JAK2 (0.50) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL3034183 | 0.86 | NTRK1 (0.71) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL13904424 | 0.84 | JAK2 (0.50) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL13904301 | 0.84 | JAK2 (0.48) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL13904289 | 0.84 | JAK2 (0.48) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL3952476 | 0.84 | AURKA (0.53) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL4005488 | 0.83 | JAK2 (0.47) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL13904425 | 0.82 | JAK2 (0.48) | NTRK1AURKAGRK6IGF1RGRK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009027736-A2 | 2,4 DIAMINOPYRIMID'LNES FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS AND CANCER | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | WO | disclosed |