Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 4/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22061376 | 0.98 | CHEK1 (0.43) | CHEK1LIMK1CDC7CCNE1CDK2 | |
| SCHEMBL22061378 | 0.97 | CHEK1 (0.37) | CHEK1LIMK1CDC7CCNE1CDK2 | |
| SCHEMBL22061419 | 0.87 | CES1 (0.31) | CES1 | |
| SCHEMBL22061418 | 0.79 | CDC7 (0.36) | CHEK1LIMK1CDC7CCNE1CDK2 | |
| SCHEMBL22061375 | 0.70 | PDE7A (0.36) | CHEK1LIMK1CDC7CCNE1CDK2 | |
| SCHEMBL22061417 | 0.70 | PDE7A (0.31) | PDE7AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL22061372 | 0.69 | PDE7A (0.38) | CHEK1LIMK1CDC7CCNE1CDK2 | |
| SCHEMBL614653 | 0.69 | CDC7 (0.57) | CHEK1LIMK1CDC7CCNE1CDK2 | |
| SCHEMBL22061373 | 0.67 | TTR (0.35) | PDE7AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL9236756 | 0.67 | CHEK1 (0.66) | CHEK1LIMK1CDC7CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020108619-A1 | MNK INHIBITOR | 上海迪诺医药科技有限公司 | 2020-06-04 | — | — | WO | disclosed |