Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.57 |
| ▸ | CDK2 | P24941 | 7/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.57 |
| ▸ | DBF4 | Q9UBU7 | 7/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL612349 | 0.75 | CDC7 (0.54) | CDC7CCNE1CDK2ROCK1DBF4 | |
| SCHEMBL614251 | 0.73 | CDC7 (1.00) | CDC7CCNE1CDK2ROCK1DBF4 | |
| SCHEMBL613695 | 0.72 | CDC7 (1.00) | CDC7CCNE1CDK2ROCK1DBF4 | |
| SCHEMBL614605 | 0.72 | CDC7 (1.00) | CDC7CCNE1CDK2ROCK1DBF4 | |
| SCHEMBL614124 | 0.71 | CDC7 (0.66) | CDC7CCNE1CDK2ROCK1DBF4 | |
| SCHEMBL29403990 | 0.71 | PDE7A (0.40) | CDC7CCNE1CDK2ROCK1DBF4 | |
| SCHEMBL611907 | 0.70 | CDC7 (0.67) | CDC7CCNE1CDK2ROCK1DBF4 | |
| SCHEMBL614314 | 0.70 | CDC7 (0.95) | CDC7CCNE1CDK2ROCK1DBF4 | |
| SCHEMBL22060802 | 0.69 | CHEK1 (0.41) | CDC7CCNE1CDK2ROCK1DBF4 | |
| SCHEMBL612385 | 0.69 | CDC7 (1.00) | CDC7CCNE1CDK2ROCK1DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403857-B1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2013-12-04 | — | — | EP | disclosed |
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | CDC7, CDK7, DTYMK | CDC7 1/4885CCNE1 158/4885CDK2 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.