Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 19/20 | 0.67 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.66 |
| ▸ | MMP2 | P08253 | 4/20 | 0.65 |
| ▸ | MMP13 | P45452 | 2/20 | 0.61 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.61 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20708173 | 0.88 | ADAMTS5 (0.63) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL23745396 | 0.83 | ADAMTS5 (0.72) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL17871521 | 0.81 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL19691673 | 0.81 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP13ADAMTS4ADAMTS1 | |
| SCHEMBL17871227 | 0.80 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL17871350 | 0.80 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL17884739 | 0.80 | ADAMTS5 (0.64) | ADAMTS5ADAM17MMP2ADAMTS4 | |
| SCHEMBL17884738 | 0.80 | ADAMTS5 (0.64) | ADAMTS5ADAM17MMP2ADAMTS4 | |
| SCHEMBL31121194 | 0.80 | ADAMTS5 (0.69) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL23745413 | 0.80 | ADAMTS5 (0.69) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468961-B1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2020-06-10 | — | — | EP | disclosed |