Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 15/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 9/20 | 0.41 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701863 | 0.82 | ADAM17 (0.65) | ADAM17ADAMTS5ADAM10ADAMTS4MMP12 | |
| SCHEMBL21403983 | 0.82 | ADAM17 (0.65) | ADAM17ADAMTS5ADAM10ADAMTS4MMP12 | |
| SCHEMBL19701857 | 0.75 | ADAM17 (0.78) | ADAM17ADAMTS5ADAMTS4 | |
| SCHEMBL22063782 | 0.75 | ADAM17 (0.71) | ADAM17ADAMTS5 | |
| SCHEMBL22022889 | 0.75 | ADAM17 (0.47) | ADAM17ADAMTS5ADAM10ADAMTS4MMP12 | |
| SCHEMBL19702769 | 0.71 | ADAM17 (0.64) | ADAM17ADAMTS5 | |
| SCHEMBL19691889 | 0.70 | ADAM17 (0.69) | ADAM17ADAMTS5ADAM10ADAMTS4MMP12 | |
| SCHEMBL21403958 | 0.70 | ADAM17 (0.69) | ADAM17ADAMTS5ADAM10ADAMTS4MMP12 | |
| SCHEMBL19703101 | 0.70 | ADAM17 (0.64) | ADAM17ADAMTS5 | |
| SCHEMBL19702759 | 0.67 | MAPT (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468961-B1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2020-06-10 | — | — | EP | disclosed |